From last.fm:

Holy White Hounds is an apt name for the quartet’s endearing but feral alt-rock. The moniker also conjures the band’s origins as small town underdogs who are rising to earn national prominence. When pressed on the significance of the handle, lead vocalist and guitarist Brenton Dean states: "We're dirty but we're not unclean. We're mangy, but you'd still let us sleep in your bed.” For young kids with guitars, prodigious musical gifts, and aspirations of being professional musicians Read more on Last.fm